Does CBD Oil Work for Migraines?

Does CBD Oil Work for Migraines?

CBD Oil for Migraines

Toward the end associated with the century that is 19th cannabis had been a main-stream therapy for preventing and relieving migraines along with other kinds of headaches. Numerous physicians advocated for the use through to the 1940s, whenever cannabis ended up being taken off the formal pharmacopeias due to its “high prospect of abuse” 1+, 2.

The current legalization of medical marijuana and CBD oil in many nations worldwide revived the almost-forgotten utilization of cannabis for headaches. But, it is crucial to notice that the sole use that is medical of authorized because of the Food And Drug Administration is always to reduce seizures in 2 types of epilepsy 3.

Migraines along with other kinds of headaches are, after arthritis, the painful conditions many commonly enhanced with CBD oil. In a study on 1500 medical CBD users, about one away from six reported struggling with headaches 4.

30% of medical cannabis users reported performing this to alleviate migraines as well as other headaches in 2 studies on very nearly 2500 individuals. But, the absolute most variety that is popular them was “OG Shark,” a THC-rich hybrid strain by having a low CBD content 5, 6.

This actually leaves us aided by the relevant question: does CBD oil alone relieve migraines as well as other kinds of headaches or must you simply just take THC-containing cannabis strains to obtain the pain-relieving advantages? Let’s look in the technology of CBD first to obtain the responses.

How Exactly Does It Work?

No matter what the kind, headaches involve an overactivation of nerves attached to blood vessels when you look at the mind (trigeminovascular system) 2, 7+.

Released vessel-widening proteins (CGRP and substance P) and messengers (NO) enhance blood circulation, which stimulates discomfort receptors on neurological cells when you look at the head and neck. Headaches certainly are a result that is direct of stimulation, while medications for headaches frequently block these receptors 2, 7+.

Boosts cannabinoids that are natural

The system that is endocannabinoid composed of two receptors: CB1 and CB2. Both THC from cannabis together with cannabinoids obviously made by the human anatomy, such as for instance anandamide, relieve pain by activating these receptors 8, 10, 11.

CBD differs from the others: it blocks in place of activates these receptors. Nevertheless, it prevents anandamide from being broken down. Interestingly, a concept through the very early century that is 21st migraines (along with other chronic pain conditions) with low anandamide levels 12, 10, 13, 14, 15.

In fact, further studies revealed that folks – and specially ladies – with migraines usually have less anandamide into the spinal fluid and platelets 16, 17, 18.

Exactly the same had been real in people who have headaches from overusing painkillers; after they withdrew through the medications, that they had less anandamide breakdown and discomfort 19, 20.

People who have chronic headaches have actually lower anandamide levels and higher CGRP and NO production. CB1 activation by anandamide and cannabinoids that are synthetic the creation of CGRP with no, which prevents (trigeminovascular) neurological overstimulation and headaches 21, 22, 23, 24, 16.

Activates Serotonin Receptors

As hinted above, anandamide reduces migraines by activating CB1. In rats, blockers regarding the serotonin receptor 5HT(1B/1D) prevented anandamide from activating CB1. This receptor features a role that is well-known relieving headaches as well as its activators (called triptans) are traditional drugs for migraines 25, 26, 27.

CBD may reduce neurological discomfort by activating another serotonin receptor (5HT1A), which can be found in the back in the place of in the head 28|relative head28, 29, 30, 31.

Activates the TRPV1 Receptor

CBD and anandamide can bind to a receptor associated with inflammatory pain (TRPV1). Its activation causes the production of CGRP, which increases blood circulation to your trigeminal nerves. This implies that CBD might cause headaches 14, 32, 33, 34, 35.

However, repeated TRPV1 activation reduces sensitiveness to discomfort. Indeed, a nose spray because of the chili pepper compound capsaicin – which also activates this receptor – relieved migraines in a trial that is small 8 individuals 14, 36+.

Obstructs Glutamate

Alterations in eyesight, flexibility, or message called aura typically precede migraine attacks. These harbingers that are migraine due to glutamate overactivation within the brain. Anandamide, THC, and cannabinoids that are synthetic glutamate receptors, suggesting they help alleviate problems with auras 2, 37, 38, 39, 40.

Reduces Inflammation and Autoimmunity

Autoimmune conditions may trigger migraines along with other kinds of headaches when they result irritation regarding the arteries into the mind. Certainly, conditions such as for example multiple sclerosis, lupus, Sjцgren problem, and syndrome that is antiphospholipid related to regular headaches 41.

CBD may alleviate headaches in people who have these conditions through its strong activity that is anti-inflammatory. The production is reduced by it of pro-inflammatory messengers (such as for example IL-1beta, IL-6, TNF-alpha, IFN-gamma. NO, and prostaglandins) while enhancing the amounts of the anti inflammatory cytokines IL-4 and IL-10 43, 44, 45, 46, 47.

Alternatively, it could avoid the apparent symptoms of autoimmune disorders by cbd curbing the response that is immune. For example, CBD prevented T cells from building and multiplying up when you look at the brains of mice with multiple sclerosis – while reducing the autoimmune-linked Th17 reaction 48, 49.

Whenever Does It Work?


In a research on over 100 individuals with migraines making use of medicinal cannabis (with both CBD and THC), 85% reported paid down pain and frequency 50 that is migraine.

A preparation with more CBD than THC prevented attacks as effectively as a migraine drug (amitriptyline) in a clinical trial on 79 people with chronic migraines. a dose that is additional the assaults paid down pain. Likewise, 3 hefty cannabis smokers began having migraines once they stopped; one got rest from smoking again 51.

THC may account fully for a great element of these results. THC alone prevented migraine assaults and reduced pain in rats. On the other hand, its overuse might have the contrary effect: high doses increased sensitivity to repeated neurological stimulation – a suspected migraine trigger 53, 54.

Taken together, there’s no proof that CBD oil improves migraines. Studies in rats even claim that THC instead of CBD will be the cannabinoid accountable for the pain sensation relief seen in individuals cannabis that are using for migraines.

Other kinds of Headaches

In research on over 100 individuals with cluster headaches, 45% utilized cannabis but just 25% experienced relief while 22percent felt even worse 55.

In a single report, leisure marijuana and synthetic THC (dronabinol) enhanced regular cluster headaches in an adolescent. The advantage had been most most likely from THC, maybe maybe not CBD 56.

In an endeavor on 13 people who have headaches from overusing painkillers, cannabis preparations pain that is reduced. But, the planning using the greatest THC content (oil) was more efficient. In accordance with this, a artificial THC element (nabilone) reduced discomfort and also the dependence on painkillers a lot better than ibuprofen in another test on 26 individuals 57, 58.

Into the temporary, THC as well as other CB1 activators additionally relieved headaches from painkillers in rats. But, their repeated use increased sensitiveness to discomfort meaning that is might trigger migraines 54.

Both medical cannabis and an artificial THC element (dronabinol) relieved headaches in 2 ladies with a high stress within the brain (pseudotumor cerebri) 59+, 60.

A couple of clinical and animal studies recommend that CBD is possibly ineffective for group headaches and headaches from overusing painkillers. THC is apparently the only cannabinoid offering some pain alleviation, nevertheless the proof continues to be restricted.


There aren’t any clinical studies testing CBD alone for headaches. Many of them utilized cannabis preparations with variable quantities of THC and CBD.

Many people with migraines prefer THC-rich cannabis strains. Plus, synthetic THC analogs had been additionally effective. This implies that migraine relief requires direct activation that is CB1 only THC is likely to attain. Having said that, CBD may slightly assist by boosting anandamide levels.

CBD Oil Dosage for Migraines


Because CBD just isn’t authorized for migraines or some other forms of headaches, there isn’t any dose that is official. There’s no confirmed dosage either because CBD alone hasn’t been tested in medical studies. The only study evaluating an item greater in CBD than in THC (9% vs 0.4%) utilized a dosage of 200 mg (supplying 18 mg CBD) a day. Nevertheless, we can’t rule out the share of the THC content to your results 51+.

We could furthermore calculate dose on the basis of the instructions from manufacturers and users.

One maker of the oil that is commercial formulated for migraines recommends 1 mL (providing 33 mg CBD) per day.

Natural health blog sites and users choose reduced doses (15-25 mg/day). They often suggest you start with a low dosage and increasing it until noticing pain-relieving results. It’s crucial to achieve this slowly, since high doses may trigger migraines while increasing hassle intensity 61.

Whatever the case, don’t try CBD oil or every other unverified treatments for migraines and headaches without consulting the doctor upfront. Check with your physician if CBD oil might help for you personally and just exactly what dose and form that is delivery be much better for your needs.

Just how to make use of

CBD oil is available in different kinds. Your kind of option might rely on your types of hassle 62+:

  • Vaping, mouth sprays, and oil tinctures are consumed quickly and supply short-term relief of pain. They might operate better for cyclically-arising headaches such as for instance group headaches.
  • Capsules, edibles, and teas release the CBD more slowly however their effects longer that is last. They may be better for conditions with constant pain such as for instance headaches from overusing painkillers.

Although migraine discomfort just isn’t constant, slow-release CBD kinds could be far better (according to CBD’s discussion with all the TRPV1 receptor). Acute CBD doses may trigger attacks that are migraine repeated doses decrease pain perception.

Anecdotal proof from internet forums advises using cannabis that are medicinal soon after just starting to sense the start of a migraine or cluster hassle attack 61.

Most useful CBD Oil for Migraines

As well as choosing a CBD oil modified to your allowance (you might want to determine the purchase price per mL or mg to compare brands that are different, it’s also wise to measure the product quality. Read here on how to select the best CBD oil.


The viewpoints indicated in this area are solely those of CBD oil users whom may or might not have medical or training that is scientific. Their reviews usually do not express the opinions of SelfHacked. SelfHacked will not endorse any product that is specific solution, or therapy.

Never consider individual experiences as medical advice. Never postpone or disregard looking for expert advice that is medical your medical professional or other qualified medical providers as a result of one thing you’ve got continue reading SelfHacked. We recognize that reading specific, real-life experiences could be a helpful resource, however it is never a replacement for health-related advice, diagnosis, or treatment from the healthcare provider that is qualified.

The absolute most typical hassle type among CBD oil users was migraine, followed closely by stress hassle, and frustration from painkiller overuse or conditions such as fibromyalgia. A lot of them were satisfied and reported pain relief that is good. The users reported some added benefits such as improving sleep quality and curbing anxiety in several cases.

Some users reported that the oil didn’t work that it made them drowsy and fatigued for them or. CBD oil also caused headaches in certain social individuals using it at high doses.


Most people with migraines utilize THC-rich cannabis strains, although some choose CBD oil. No studies that are clinical yet tested CBD oil alone for headaches or migraines.

Animal studies reveal that CBD oil may relieve headaches – but just into the run that is long most likely not along with THC.

Sudden surges in CBD, such as for example from vaping, could potentially cause migraines. But taken long-lasting, CBD may relieve pain perception and stop migraine auras. It primarily functions boosting your normal cannabinoid bliss particles.

CBD oil can also be an choice for those who have migraines and headaches from autoimmune diseases like lupus and numerous sclerosis. In these instances, it likely helps by lowering mind irritation and suppressing autoimmunity.

Opt for capsules or edibles and simply take them every time for the greatest outcomes.

Vendors offer CBD oil on Amazon, but some of these do not satisfy quality requirements. Some don’t even specify the CBD content inside their items, while others offer hemp oil with little to no or no CBD. Many of these vendors are to not be trusted.

We recommend the following brand name, which specifies quality procedures and CBD content within their items:

This area contains sponsored links, which means that we might receive a percentage that is small of profits from your own purchase, as the cost continues to be the exact same to you personally. The arises from your purchase help our work and research. Many thanks for your support!

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